By car:
From the north: along the A1 motorway Florence-Rome, exit at Valdichiana.

From the south: along the A1 motorway Rome-Florence, exit at Orte and take the S. S. 3 Flaminia to Foligno.
Along the A14 Adriatica motoway, exit at Civitanova Marche (Mc); take the S.S. 77 - Val di Chienti to Foligno.
Along the E45 Cesena-Orte highway that crosses the whole of Umbria from top to bottom. Take the S.S. 75 Centrale Umbra to Foligno.

By train:
From the north:
Take the Florence-Rome line and change at Terontola for Foligno.

From the south:
Take the Rome-Orte-Florence line and continue at Orte along the Foligno-Ancona line. From the Adriatic coast, take the Ancona-Foligno line.

By plane: The Sant'Egidio airport is just 26 km from Foligno. Rome's Fiumicino airport is 195 km away.